De Montis M G, Gambarana C, Meloni D
Institute of Pharmacology, University of Siena, Italy.
Eur J Pharmacol. 1993 Nov 9;249(2):179-83. doi: 10.1016/0014-2999(93)90430-p.
alpha-Methyl-para-tyrosine, co-administered with imipramine to rats at a dose that only partially inhibits tyrosine hydroxylase, has been found to prevent completely the decrease of dopamine D1 receptor function. The present report shows that, in the same experimental conditions, alpha-methyl-para-tyrosine significantly antagonized the capacity of imipramine to prevent the development of learned helplessness behavior in rats. This suggests that a catecholaminergic mechanism is crucial in determining the effect of imipramine on the development of learned helplessness behavior. alpha-Methyl-para-tyrosine co-administration also prevented imipramine-induced down-regulation of beta-adrenoceptor function.
α-甲基对酪氨酸与丙咪嗪以仅部分抑制酪氨酸羟化酶的剂量共同给予大鼠时，已发现它能完全防止多巴胺D1受体功能的下降。本报告表明，在相同实验条件下，α-甲基对酪氨酸显著拮抗了丙咪嗪预防大鼠习得性无助行为发展的能力。这表明儿茶酚胺能机制在决定丙咪嗪对习得性无助行为发展的影响方面至关重要。α-甲基对酪氨酸共同给药还防止了丙咪嗪诱导的β-肾上腺素能受体功能下调。
