Meloni D, Gambarana C, De Montis M G, Dal Prá P, Taddei I, Tagliamonte A
Institute of Pharmacology, University of Siena, Italy.
Pharmacol Biochem Behav. 1993 Oct;46(2):423-6. doi: 10.1016/0091-3057(93)90374-3.
Dizocilpine coadministered with imipramine (IMI) through an SC-implanted osmotic minipump completely prevents the occurrence of behavioral supersensitivity to quinpirole, as well as the decrease of dopamine D1 and beta-adrenergic receptor function. The present report shows that, in the same experimental conditions, dizocilpine completely antagonized the capacity of IMI to prevent the development of the learned helplessness behavior in rats. Thus suggesting that the blockade of NMDA receptors also antagonizes the antidepressant effect of IMI. Interestingly, rats acutely treated with dizocilpine 30 min before the inescapable shock session behaved similarly to naive animals during the escape test session.
通过皮下植入的渗透微型泵将地佐环平与丙咪嗪（IMI）共同给药，可完全防止对喹吡罗产生行为超敏反应，以及多巴胺D1和β-肾上腺素能受体功能的降低。本报告表明，在相同的实验条件下，地佐环平完全拮抗了IMI预防大鼠习得性无助行为发展的能力。因此表明，NMDA受体的阻断也拮抗了IMI的抗抑郁作用。有趣的是，在不可逃避电击试验前30分钟对地佐环平进行急性处理的大鼠，在逃避试验期间的行为与未处理的动物相似。
