Brair M E, Brabin B J, Milligan P, Maxwell S, Hart C A
Liverpool School of Tropical Medicine, UK.
Lancet. 1994 Jan 22;343(8891):208-9. doi: 10.1016/s0140-6736(94)90991-1.
Placental malaria may limit antibody transfer to the fetus. We compared concentrations of tetanus antibody in paired maternal-cord sera from 224 women living in a malarious area of Papua New Guinea. With heavy placental infection (> 35 parasites per 200 white cells) the average cold tetanus antibody corresponding to a maternal level of 1 IU/mL was 0.18 (95% CI 0.12-0.26); corresponding figures after light (< 35 parasites per 200 white cells) or no infection were 0.23 (0.14-0.34) and 0.82 (0.57-1.21), respectively. About 10% of babies born to mothers with a placenta heavily infected with Plasmodium falciparum may fail to acquire protective levels of tetanus antibody despite adequate maternal antibody.
胎盘疟疾可能会限制抗体向胎儿的转移。我们比较了来自巴布亚新几内亚疟疾流行地区的224名女性配对母血和脐血血清中的破伤风抗体浓度。胎盘严重感染（每200个白细胞中寄生虫>35个）时，母体水平为1 IU/mL对应的平均破伤风抗体效价为0.18（95%可信区间0.12 - 0.26）；轻度感染（每200个白细胞中寄生虫<35个）或未感染后的相应数值分别为0.23（0.14 - 0.34）和0.82（0.57 - 1.21）。尽管母体抗体充足，但约10%胎盘被恶性疟原虫严重感染的母亲所生婴儿可能无法获得具有保护作用水平的破伤风抗体。
