压力诱导的大鼠神经传递紊乱与自发行为：一种精神病动物模型

Pressure-induced disorders in neurotransmission and spontaneous behavior in rats: an animal model of psychosis.

作者信息

Abraini J H, Ansseau M, Fechtali T

机构信息

Unité de Neuropsychiatrie, C.H.U. Sart Tilman, Liège, Belgium.

出版信息

Biol Psychiatry. 1993 Nov 1;34(9):622-9. doi: 10.1016/0006-3223(93)90154-6.

DOI:10.1016/0006-3223(93)90154-6

PMID:7904834

Abstract

Disorders in neurotransmission and spontaneous behavior in rats exposed to a high pressure helium-oxygen mixture that shows interesting parallels with the dopaminergic hypothesis of schizophrenia at both the biochemical and the therapeutic responding levels are reviewed. Furthermore, as human subjects exposed to a very high pressure have shown psychotic episodes, we conclude that the pressure-induced disorders in neurotransmission and spontaneous behavior in rats could constitute a valid animal model of schizophreniform psychosis and a useful tool for both the investigation of the biological mechanisms underlying schizophrenia and the development of new antipsychotic drugs.

摘要

本文综述了暴露于高压氦氧混合气的大鼠的神经传递紊乱和自发行为，这些紊乱在生化和治疗反应水平上都与精神分裂症的多巴胺能假说有有趣的相似之处。此外，由于暴露于极高压力下的人类受试者出现了精神病发作，我们得出结论，压力诱导的大鼠神经传递紊乱和自发行为可能构成精神分裂症样精神病的有效动物模型，以及用于研究精神分裂症潜在生物学机制和开发新型抗精神病药物的有用工具。