Velázquez A, Rosa del Angel A, Feria-Velasco A
División de Patología Experimental, IMSS, Guadalajara, Jalisco, México.
Arch Med Res. 1993 Spring;24(1):33-6.
To determine the effect of low protein and corn-based diets on the maturation of cerebellum, three groups of young rats were fed during a period of 6 weeks with different diets; 23 and 8% of protein (Purina-Chow base) and a corn-based diet (8% protein). At the end of that period, the concentration of free amino acids in the cerebellum was measured. Glutamic acid, glycine, glutamine and serine showed the highest values in all groups studied. Corn-based diet group showed the lowest free amino acid concentration compared to that of the control group, with a significant diminution in the concentration of glutamic acid, lysine, tyrosine and histidine. Differences between essential and nonessential amino acids were not observed in all groups studied. Although corn-based diet did not induce specific changes as those reported in severe malnutrition, its effects on the concentration of some amino acids other than tryptophan could have some physiological correlations which need to be further studied.
为确定低蛋白和玉米基饮食对小脑成熟的影响，将三组幼鼠在6周时间内喂食不同饮食；蛋白质含量分别为23%和8%（以普瑞纳饲料为基础）以及一种玉米基饮食（蛋白质含量8%）。在该时间段结束时，测量了小脑中游离氨基酸的浓度。谷氨酸、甘氨酸、谷氨酰胺和丝氨酸在所有研究组中显示出最高值。与对照组相比，玉米基饮食组的游离氨基酸浓度最低，谷氨酸、赖氨酸、酪氨酸和组氨酸的浓度显著降低。在所有研究组中未观察到必需氨基酸和非必需氨基酸之间的差异。尽管玉米基饮食并未像严重营养不良中报道的那样引起特定变化，但其对除色氨酸以外的某些氨基酸浓度的影响可能具有一些生理相关性，有待进一步研究。
