Gurin V N, Dudina T V, Elkina A I, Kandybo T S
Radiats Biol Radioecol. 1993 Sep-Oct;33(5):674-80.
In experiments with mature Wistar male rats exposed to 25- and 50-fold fractionated doses of external X-ray radiation (0.5 Gy) and daily probe-assisted administration of plumbum acetate (100, 10, 5 mg/kg), similar, but differently marked changes in transmitter relationship in some CNS structures resembling the earlier found neurotransmitter disbalance during chronic stress of different ethiology were revealed. Combined exposure to plumbum and radiation led to more sustained and prolonged disorders to transmitter relationship associated with a sharp decrease in specific binding of corticosterone in CNS glucocorticoid-sensitive structures.
在对成年雄性Wistar大鼠进行的实验中，使其暴露于25倍和50倍分级剂量的外部X射线辐射（0.5戈瑞）下，并每日通过探针辅助给予醋酸铅（100、10、5毫克/千克），结果显示，在某些中枢神经系统结构中，递质关系发生了类似但标记不同的变化，类似于早期在不同病因的慢性应激期间发现的神经递质失衡。铅和辐射的联合暴露导致递质关系出现更持久、更长期的紊乱，同时中枢神经系统糖皮质激素敏感结构中皮质酮的特异性结合急剧减少。
