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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

University of Tennessee College of Veterinary Medicine, Knoxville.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Oct;106(2):483-7. doi: 10.1016/0742-8413(93)90167-j.

Plasma amine oxidase (PAO), an enzyme that oxidizes primary amines is generally assumed to be present in the sera of all mammals. 2. We studied plasma from eleven different mammals to determine if they could oxidize a group of amines of biomedical interests. 3. Our results indicate that PAO is not present in all mammals and also that substrate specificity of the enzyme varies within the species tested. Rodents which are frequently used as animal models in pharmacology and toxicology do not contain PAO. 4. The common polyamines, spermine, spermidine and putrecine were oxidized only by bovine plasma.

血浆胺氧化酶（PAO）是一种氧化伯胺的酶，通常认为所有哺乳动物的血清中都存在该酶。2. 我们研究了11种不同哺乳动物的血浆，以确定它们是否能够氧化一组具有生物医学意义的胺类。3. 我们的结果表明，并非所有哺乳动物都存在PAO，而且在所测试的物种中，该酶的底物特异性也有所不同。在药理学和毒理学中经常用作动物模型的啮齿动物不含PAO。4. 常见的多胺，如精胺、亚精胺和腐胺，仅被牛血浆氧化。

University of Tennessee College of Veterinary Medicine, Knoxville.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Oct;106(2):483-7. doi: 10.1016/0742-8413(93)90167-j.

Plasma amine oxidase (PAO), an enzyme that oxidizes primary amines is generally assumed to be present in the sera of all mammals. 2. We studied plasma from eleven different mammals to determine if they could oxidize a group of amines of biomedical interests. 3. Our results indicate that PAO is not present in all mammals and also that substrate specificity of the enzyme varies within the species tested. Rodents which are frequently used as animal models in pharmacology and toxicology do not contain PAO. 4. The common polyamines, spermine, spermidine and putrecine were oxidized only by bovine plasma.

血浆胺氧化酶（PAO）是一种氧化伯胺的酶，通常认为所有哺乳动物的血清中都存在该酶。2. 我们研究了11种不同哺乳动物的血浆，以确定它们是否能够氧化一组具有生物医学意义的胺类。3. 我们的结果表明，并非所有哺乳动物都存在PAO，而且在所测试的物种中，该酶的底物特异性也有所不同。在药理学和毒理学中经常用作动物模型的啮齿动物不含PAO。4. 常见的多胺，如精胺、亚精胺和腐胺，仅被牛血浆氧化。