Stewart D J
McGill University, McGill Vascular Biology Group, Royal Victoria Hospital, Montreal, Quebec, Canada.
Eur Heart J. 1993 Nov;14 Suppl I:48-54.
Endothelin-1 is a potent endothelium-derived vasoconstrictor peptide which also has important growth promoting effects on other cellular elements of the vascular wall. Increased local expression and release of endothelin-1 may therefore contribute to abnormal vascular tone and structure in paracrine fashion. Evidence of increased pulmonary production of endothelin-1 by the lung in patients with primary pulmonary hypertension is reviewed, including increased release across the pulmonary circulation and increased vascular expression of the peptide and its mRNA. However, circulating endothelin-1 might also have a humoral action on distant vascular beds. Changes in plasma endothelin-1 in response to postural change and chronic heart failure support a role for this potent vasoconstrictor factor in the neurohumoral response to haemodynamic stress. Thus, like other vascular regulatory mechanisms, the endothelin system might play a dual role in the control of vascular function with both local tissue and circulatory components.
内皮素-1是一种强效的内皮源性血管收缩肽，对血管壁的其他细胞成分也具有重要的促生长作用。因此，内皮素-1局部表达和释放增加可能以旁分泌方式导致血管张力和结构异常。本文综述了原发性肺动脉高压患者肺组织中内皮素-1生成增加的证据，包括经肺循环释放增加以及该肽及其信使核糖核酸的血管表达增加。然而，循环内皮素-1对远处血管床也可能具有体液作用。体位改变和慢性心力衰竭时血浆内皮素-1的变化支持这种强效血管收缩因子在对血流动力学应激的神经体液反应中发挥作用。因此，与其他血管调节机制一样，内皮素系统在血管功能调控中可能通过局部组织和循环成分发挥双重作用。
