Stewart D
University of Toronto, St Michael's Hospital, Ontario.
Can J Cardiol. 1998 Jul;14 Suppl D:11D-13D.
Endothelin is a very potent vasoconstrictor peptide produced by the vascular endothelium. Several studies have shown that the endothelin system is activated in various cardiovascular conditions, including myocardial infarction, heart failure and pulmonary hypertension. The known actions of the endothelin-1 isoform suggest that it may be an important mediator in several of the pathophysiological manifestations of heart failure. Data on the potential value of endothelin antagonists in heart failure are reviewed.
内皮素是一种由血管内皮产生的强效血管收缩肽。多项研究表明，内皮素系统在多种心血管疾病中被激活，包括心肌梗死、心力衰竭和肺动脉高压。内皮素-1亚型的已知作用表明，它可能是心力衰竭几种病理生理表现的重要介质。本文综述了内皮素拮抗剂在心力衰竭中的潜在价值的数据。
