用¹³³氙和安格尔闪烁照相机对兔肾超急性异种移植排斥反应进行肾血流量研究（作者译）

[Renal blood flow investigations with 133xenon and the Anger scintillation camera in the hyperacute xenograft rejection of the rabbit kidney (author's transl)].

作者信息

Heidenreich P, Erhardt W, Oberdorfer M, Krüger P, Pielsticker K, Hör G

出版信息

Res Exp Med (Berl). 1976 Aug 25;168(2):143-56. doi: 10.1007/BF01851904.

DOI:10.1007/BF01851904

Abstract

The aim of this study was to demonstrate the advantage and validity of 133Xe-washout externally monitored by the scintillation camera. Until now there were no reports on quantitative blood flow studies in Hyperacute rejection of transplanted kidneys using a scintillation camera. Within 35 minutes after e-vivo hemoperfusion of rabbit kidneys by cats we found a simultaneous progressive decrease of renal blood flow, renal cortical blood flow as well as of the intrarenal distribution of renal cortical blood flow in all cases. The hyperacute rejection of xenografts could be verified in every case histologically. Using the scintillation camera we were able to detect regional perfusion defects caused by artifical air embolism as well as by preexisting cortical infarction.

摘要

本研究的目的是证明闪烁相机外部监测的¹³³Xe洗脱的优势和有效性。到目前为止，尚无关于使用闪烁相机对移植肾超急性排斥反应进行定量血流研究的报道。在猫对兔肾进行体外血液灌注后的35分钟内，我们发现所有病例的肾血流量、肾皮质血流量以及肾皮质血流量的肾内分布均同时逐渐减少。在每个病例中均可通过组织学证实异种移植物的超急性排斥反应。使用闪烁相机，我们能够检测到由人工空气栓塞以及先前存在的皮质梗死引起的局部灌注缺损。