Schmitz-Feuerhake I, Falkenreck-Herbst I, Coburg A J, Wonigeit K, Gerhard K, Prévôt H
Eur J Clin Invest. 1978 Apr;8(2):75-80. doi: 10.1111/j.1365-2362.1978.tb00815.x.
Non-invasive measurement of organ blood flow can be achieved by tracing the elimination patterns of 133Xe administered by inhalation. An adaption of the method for the estimation of renal blood flow was developed. The 133Xe is accumulated in the tissue by re-breathing for 1 min and the time course of its washout from the kidney is followed for 14 min thereafter. Normal values were determined in ten dogs and forty-five healthy human volunteers. In man they were similar to results obtained with 131I-hippuran clearance. When flow rates were between 250 and 600 ml/100 g/min the correlation coefficient was 0.84. Only in cases with high cortex flow rates (greater than 600 ml/100 g/min) did the inhalation method give values higher than those determined by the 131I-hippuran clearance. In dogs the results closely correlated with results obtained by direct intra arterial xenon injection (r = 0.96). The value of the inhalation method in routine examination of patients with kidney transplants and its suitability for the early detection of ongoing rejection is demonstrated.
通过追踪吸入的¹³³Xe的清除模式可以实现对器官血流的无创测量。已开发出一种该方法的改良版用于估算肾血流量。¹³³Xe通过再呼吸1分钟在组织中蓄积，此后跟踪其从肾脏清除的时间过程14分钟。在10只狗和45名健康人类志愿者中确定了正常值。在人类中，这些值与用¹³¹I-马尿酸清除法获得的结果相似。当血流速率在250至600 ml/100 g/min之间时，相关系数为0.84。仅在皮质血流速率较高（大于600 ml/100 g/min）的情况下，吸入法给出的值才高于¹³¹I-马尿酸清除法测定的值。在狗中，结果与通过直接动脉内注入氙气获得的结果密切相关（r = 0.96）。证明了吸入法在肾移植患者常规检查中的价值及其对早期检测正在发生的排斥反应的适用性。
