掌腱膜挛缩症中的真皮树突状细胞：皮肤与发病机制之间的联系？

Dermal dendrocytes in Dupuytren's disease: a link between the skin and pathogenesis?

作者信息

Sugden P, Andrew J G, Andrew S M, Freemont A J

机构信息

Department of Pathological Sciences, University of Manchester, Salford, UK.

出版信息

J Hand Surg Br. 1993 Oct;18(5):662-6. doi: 10.1016/0266-7681(93)90030-j.

DOI:10.1016/0266-7681(93)90030-j

PMID:7905015

Abstract

The skin has previously been implicated in the process of Dupuytren's disease. The dermal dendrocyte is a factor XIIIa positive cell, which has been found in normal skin and some pathological conditions associated with fibrosis. In this study we examined the distribution of factor XIIIa positive cells in and around tissue from Dupuytren's disease. Immunohistochemistry was performed using a panel of antibodies for factor XIIIa, macrophages (CD68 and MAC387) and MHC II. Many factor XIIIa positive dendritic cells were present in and around Dupuytren's tissue; fewer CD68 and MHC II positive cells and very few MAC387 cells were seen. We propose that the factor XIIIa positive cells are dermal dendrocytes. This study may indicate an important link between the skin and pathogenesis of Dupuytren's disease.

摘要

皮肤先前已被认为与掌腱膜挛缩症的发病过程有关。真皮树突状细胞是一种因子 XIIIa 阳性细胞，在正常皮肤以及一些与纤维化相关的病理状况中都有发现。在本研究中，我们检测了掌腱膜挛缩症组织及其周围因子 XIIIa 阳性细胞的分布情况。使用一组针对因子 XIIIa、巨噬细胞（CD68 和 MAC387）以及 MHC II 的抗体进行免疫组织化学检测。在掌腱膜挛缩症组织及其周围存在许多因子 XIIIa 阳性树突状细胞；可见较少的 CD68 和 MHC II 阳性细胞，而 MAC387 细胞极少。我们认为因子 XIIIa 阳性细胞是真皮树突状细胞。本研究可能表明皮肤与掌腱膜挛缩症发病机制之间存在重要联系。