Bigrigg A, Haffenden D K, Sheehan A L, Codling B W, Read M D
University Department of Obstetrics and Gynaecology, Southmead Hospital, Bristol, UK.
Lancet. 1994 Jan 1;343(8888):32-4. doi: 10.1016/s0140-6736(94)90881-8.
Large-loop excision of the transformation zone (LLETZ) has become a popular treatment for women with cervical intraepithelial neoplasia (CIN) before long-term effectiveness and safety have been fully evaluated. Women who took part in a 1990 study of the procedure have been followed-up by cervical cytology for longer than 2 years. The rate of recurrences and residual lesions was 5.0% in the first year and 0.6% in the second year. LLETZ was also effective when used as a repeat procedure, although the negative histology rate was much higher (4.7% for initial procedures and 20% for repeat procedures). 250 women from the original study group of 1000 answered a questionnaire on fertility and menstrual symptoms 3 years after LLETZ. We found no differences between these women and controls of the same age, living in the same geographical area, with a history of negative cervical smears. LLETZ is a safe and effective procedure with no effect on menstruation or fertility.
在长期有效性和安全性尚未得到充分评估之前，宫颈转化区大环形切除术（LLETZ）已成为治疗宫颈上皮内瘤变（CIN）女性的常用方法。参与1990年该手术研究的女性已接受宫颈细胞学随访超过2年。第一年复发和残留病变率为5.0%，第二年为0.6%。LLETZ作为重复手术时也有效，尽管阴性组织学率要高得多（初次手术为4.7%，重复手术为20%）。来自最初1000名研究组的250名女性在LLETZ术后3年回答了一份关于生育和月经症状的问卷。我们发现这些女性与年龄相同、生活在同一地理区域、宫颈涂片检查结果为阴性的对照组之间没有差异。LLETZ是一种安全有效的手术，对月经或生育没有影响。
