Garcia Ramos Aristoteles Mauricio, Garcia Ramos Erika Souza, Dos Reis Helena Lucia Barroso, de Rezende Ricardo Bueno
Santa Casa de Misericordia School of Science (EMESCAM), Vitoria, ES, Brazil.
Espirito Santo Federal University (UFES), Vitoria, ES, Brazil.
J Clin Med Res. 2015 Apr;7(4):220-4. doi: 10.14740/jocmr1951w. Epub 2015 Feb 9.
Large loop excision of the transformation zone (LLETZ) has been used for the diagnosis and treatment of precancerous cervical lesions, and it is the first choice of treatment in the majority of cervical pathology services. The aim of this study was to evaluate the presence of thermal artifacts, the need for serial sections, the percentage of clear and involved resection margins and the relationship between endocervical gland involvement and the severity of the lesion in samples resected using LLETZ.
A retrospective study was performed at Santa Casa de Misericordia School of Science (HSCMV), Vitoria, Espirito Santo, Brazil with a sample of 52 histopathology slides from patients submitted to conization because of abnormal cytology findings and a biopsy result of cervical intraepithelial neoplasia (CIN) 2, CIN 3 and adenocarcinoma in situ. Statistical analysis was performed using Student's t-test.
Serial sections were required to confirm diagnosis in four of 52 cases. Thermal artifacts were present in all cases, with grade I being the most common (94.2% of cases). Clear margins were found in 96.2% of cases. No association was found between glandular involvement and CIN 1 (P > 0.05); however, there was an association with CIN 2 and CIN 3 (P < 0.05).
The amount of excised tissue was sufficient, thermal artifacts were slight, resection margins were clear in most of cases, and a possible association was found between glandular involvement and the severity of the lesion.
宫颈转化区大环形切除术（LLETZ）已用于宫颈癌前病变的诊断和治疗，并且是大多数宫颈病理检查中的首选治疗方法。本研究的目的是评估使用LLETZ切除的样本中热伪像的存在情况、连续切片的必要性、切缘清晰和受累的百分比以及宫颈管腺体受累与病变严重程度之间的关系。
在巴西圣埃斯皮里图州维多利亚市的圣卡塔琳娜慈善科学学院（HSCMV）进行了一项回顾性研究，对52例因细胞学异常结果和宫颈上皮内瘤变（CIN）2、CIN 3及原位腺癌活检结果而接受锥切术的患者的组织病理学切片样本进行研究。采用学生t检验进行统计分析。
52例中有4例需要连续切片以确诊。所有病例均存在热伪像，其中I级最为常见（占病例的94.2%）。96.2%的病例切缘清晰。未发现腺体受累与CIN 1之间存在关联（P>0.05）；然而，与CIN 2和CIN 3存在关联（P<0.05）。
切除组织量充足，热伪像轻微，大多数病例切缘清晰，并且发现腺体受累与病变严重程度之间可能存在关联。
