Sato T, Sakado K, Sato S
Department of Psychiatry, Nijgata City General Hospital, Japan.
Acta Psychiatr Scand. 1993 Nov;88(5):342-9. doi: 10.1111/j.1600-0447.1993.tb03470.x.
This study attempted to identify a specific personality disorder (PD) or PD cluster that independently worsens the 4-month treatment outcome of major depression under adequate antidepressant. The material of the study was 96 consecutive outpatients with major depression. For the Axis I and Axis II diagnoses, the Structured Clinical Interview for DSM-III-R (SCID) was used. In the material, the presence of any PD significantly worsened the 4-month outcome. The discriminant function analysis, conducted to identify a specific PD or PD cluster that influences the outcome, found that the number of PD from only cluster A and the number of criteria met for only schizoid PD was significantly correlated with the 4-month outcome of depression.
本研究试图确定一种特定的人格障碍(PD)或人格障碍集群,其在足量抗抑郁药物治疗下会独立恶化重度抑郁症的4个月治疗结局。该研究的对象为96例连续性重度抑郁症门诊患者。对于轴I和轴II诊断,采用了针对《精神疾病诊断与统计手册》第三版修订本(DSM-III-R)的结构化临床访谈(SCID)。在研究对象中,任何人格障碍的存在均显著恶化了4个月的结局。为确定影响结局的特定人格障碍或人格障碍集群而进行的判别函数分析发现,仅A类人格障碍的数量以及仅符合分裂样人格障碍标准的数量与抑郁症的4个月结局显著相关。