Casada J H, Dafny N
University of Texas Medical School, Department of Neurobiology and Anatomy, Houston 77225.
Brain Res. 1993 Dec 17;631(1):124-8. doi: 10.1016/0006-8993(93)91196-y.
This study was designed to determine the type of receptor mediating the effect of ACh on BNST neurons. 45% of BNST neurons showed a dose-dependent monophasic increase in firing rate in response to ACh. Muscarinic antagonist blocked the effects of ACh. Amygdala stimulation (Amyg S) elicited excitatory responses, but atropine and hexamethonium had no effect on the Amyg S induced excitation. The experiment shows that the excitatory effect of ACh on BNST neurons is mediated by muscarinic receptors, while the excitatory effects of Amyg S on BNST neurons is not mediated by ACh.
本研究旨在确定介导乙酰胆碱（ACh）对终纹床核（BNST）神经元作用的受体类型。45%的BNST神经元对ACh呈剂量依赖性单相放电频率增加。毒蕈碱拮抗剂可阻断ACh的作用。杏仁核刺激（Amyg S）可引发兴奋性反应，但阿托品和六甲铵对Amyg S诱导的兴奋无作用。实验表明，ACh对BNST神经元的兴奋作用由毒蕈碱受体介导，而Amyg S对BNST神经元的兴奋作用不是由ACh介导的。
