Karaman A S, Uran B, Erler A
Department of Obstetrics and Gynecology, Social Security Hospital, Kütahya, Turkey.
Int J Gynaecol Obstet. 1993 Nov;43(2):177-80. doi: 10.1016/0020-7292(93)90326-r.
In this study, we evaluated the importance of the determination of serum prolactin levels in postpill amenorrheic patients.
Serum estradiol and prolactin levels were determined in 37 postpill amenorrheic patients. Bromocriptine was administered to the hyperprolactinemic group and clomiphene citrate to the normoprolactinemic group.
Hyperprolactinemia was observed in 21 patients (56.7%) and serum estradiol levels < 50 pg/ml were found in 19 of these patients. The mean prolactin level was 71.90 +/- 23.05 ng/ml in the hyperprolactinemic group. While bromocriptine had a significant effect on the length of time for menstrual bleeding to return (P < 0.001), clomifene had no effect.
No treatment is required for the postpill amenorrheic patients with normal estradiol and prolactin levels. If hyperprolactinemia is detected, bromocriptine may be used as a treatment to promote normal menstrual bleeding and ovulation.
在本研究中，我们评估了测定避孕药后闭经患者血清催乳素水平的重要性。
测定了37例避孕药后闭经患者的血清雌二醇和催乳素水平。对高催乳素血症组给予溴隐亭，对催乳素水平正常组给予枸橼酸氯米芬。
21例患者（56.7%）出现高催乳素血症，其中19例患者血清雌二醇水平<50 pg/ml。高催乳素血症组的平均催乳素水平为71.90±23.05 ng/ml。虽然溴隐亭对月经恢复出血的时间有显著影响（P<0.001），但氯米芬无效。
对于雌二醇和催乳素水平正常的避孕药后闭经患者无需治疗。如果检测到高催乳素血症，溴隐亭可作为促进正常月经出血和排卵的治疗药物。
