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敌氟虫脲对[3H]-N-乙酰葡糖胺（[3H]NAGA）掺入新蜕皮的美洲大蠊完整体壁几丁质中的影响。

Effect of diflubenzuron on incorporation of [3H]-N-acetylglucosamine ([3H]NAGA) into chitin in the intact integument from the newly molted American cockroach Periplaneta americana.

作者信息

Nakagawa Y, Matsumura F, Hashino Y

机构信息

Department of Environmental Toxicology, University of California, Davis 95616.

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Nov;106(3):711-5. doi: 10.1016/0742-8413(93)90231-9.

DOI:10.1016/0742-8413(93)90231-9
PMID:7905808
Abstract
  1. Diflubenzuron and polyoxin D clearly inhibited the incorporation of [3H]-N-acetylglucosamine ([3H]NAGA) into chitin in the isolated integument from newly molted American cockroaches under the experimental condition. 2. Upon homogenization, or tissue slicing, such an inhibitory effect of diflubenzuron on chitin synthesis totally disappeared, while that of polyoxin D did not. 3. Mitochondrial poisons (oligomycin and FCCP), protein phosphorylation modulations (8-Br-cAMP, Na3VO4 and MnCl2), potassium ionophores (valinomycin), and calmodulin inhibitor (trifluoperazine) clearly inhibited [3H]NAGA incorporation. 4. Phospholipase A2 and calcium ion significantly enhanced the [3H]NAGA incorporation.
摘要
  1. 在实验条件下，除虫脲和多氧霉素D能明显抑制[3H]-N-乙酰葡糖胺（[3H]NAGA）掺入新蜕皮的美国蟑螂离体体壁的几丁质中。2. 匀浆或组织切片后，除虫脲对几丁质合成的这种抑制作用完全消失，而多氧霉素D的抑制作用则未消失。3. 线粒体毒物（寡霉素和羰基氰对氯苯腙）、蛋白质磷酸化调节剂（8-溴环磷腺苷、钒酸钠和氯化锰）、钾离子载体（缬氨霉素）和钙调蛋白抑制剂（三氟拉嗪）能明显抑制[3H]NAGA掺入。4. 磷脂酶A2和钙离子能显著增强[3H]NAGA掺入。

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