Tsuchiya A
Department of Anesthesia, Kiryu Kousei General Hospital.
Masui. 1994 Jan;43(1):50-4.
This study was designed to evaluate the potentiation by nitrous oxide of the neuromuscular blockade by vecuronium measured by the evoked electromyogram (EMG). Vecuronium, 0.0225, 0.03 or 0.04 mg.kg-1 was given during thiamylalfentanyl anesthesia with and without nitrous oxide, and EMG of the hypothenar muscle was measured. ED50 and ED95 were 0.0271 and 0.0480 mg.kg-1 in the group receiving nitrous oxide, and 0.0304 and 0.0555 mg.kg-1 in the group not receiving nitrous oxide. Dose-response curve (DRC) constructed from log-probit transformation for the group not receiving nitrous oxide was shifted to the right by 12.4%. By multiple regression analysis it was also revealed that the magnitude of the blockade was influenced by dose, nitrous oxide, sex and body mass index (BMI). DRCs for the female patients were shifted to the left, and the those differences caused by sex were shown to increase during anesthesia without nitrous oxide. It is concluded that the potentiation by nitrous oxide of vecuronium neuromuscular blockade obtained by EMG is less than that reported measuring by mechanomyogram, and also the magnitude of the blockade is influenced by sex and BMI, but the difference caused by sex is decreased by administration of nitrous oxide.
本研究旨在通过诱发肌电图（EMG）评估氧化亚氮对维库溴铵神经肌肉阻滞的增强作用。在硫喷妥钠-阿芬太尼麻醉期间，分别在有和没有氧化亚氮的情况下给予维库溴铵，剂量为0.0225、0.03或0.04mg·kg-1，并测量小鱼际肌的EMG。接受氧化亚氮的组中，ED50和ED95分别为0.0271和0.0480mg·kg-1，未接受氧化亚氮的组中分别为0.0304和0.0555mg·kg-1。未接受氧化亚氮组通过对数-概率转换构建的剂量-反应曲线（DRC）向右移动了12.4%。多元回归分析还显示，阻滞程度受剂量、氧化亚氮、性别和体重指数（BMI）的影响。女性患者的DRC向左移动，并且在没有氧化亚氮的麻醉期间，由性别引起的差异显示增加。结论是，通过EMG获得的氧化亚氮对维库溴铵神经肌肉阻滞的增强作用小于通过机械肌电图测量所报告的增强作用，并且阻滞程度受性别和BMI的影响，但氧化亚氮的给药可减少由性别引起的差异。
