Kamizono A, Inotsume N, Fukushima S, Nakano M
Department of Pharmaceutical Services, Kumamoto University Hospital, Japan.
Biol Pharm Bull. 1993 Nov;16(11):1121-3. doi: 10.1248/bpb.16.1121.
Pharmacokinetics of sultopride enantiomers was examined following a single dose in a human, rabbits and rats. Pharmacokinetic profiles were similar between (+)- and (-)-enantiomers of sultopride in human, whereas the serum concentrations of (-)-sultopride were slightly higher than those of (+)-sultopride after i.v. administration of 50 mg/kg of racemic sultopride to rats and rabbits.
对人、兔和大鼠单次给药后舒托必利对映体的药代动力学进行了研究。舒托必利的（+）-和（-）-对映体在人体内的药代动力学特征相似，而给大鼠和兔静脉注射50mg/kg外消旋舒托必利后，（-）-舒托必利的血清浓度略高于（+）-舒托必利。
