Mokrim R, Brunet C, Cazin M, Gressier B, Luyckx M, Dine T, Robert H, Cazin J C
Laboratoire de Pharmacologie et Pharmacocinétique, Faculté de Pharmacie, Lille, France.
Methods Find Exp Clin Pharmacol. 1993 Jan-Feb;15(1):41-7.
A radioreceptor assay (RRA) was developed to determine plasma levels of amisulpride. In in vitro binding conditions, the RRA technique was sensitive (11.6 nmol/l) and reliable, with a high degree of precision. The reproducibility of the method through statistical coefficients was < 7%. This method was applied to a pilot pharmacokinetic study in rabbits following single i.v. administration of amisulpride at 10 mg/kg. The results obtained were compared with those obtained by high performance liquid chromatography method (HPLC) in order to assess the validity of this new RRA technique.
已开发出一种放射受体分析法（RRA）来测定血浆中阿立哌唑的水平。在体外结合条件下，RRA技术灵敏（11.6纳摩尔/升）且可靠，精密度高。通过统计系数得出该方法的重现性<7%。此方法应用于兔单次静脉注射10毫克/千克阿立哌唑后的初步药代动力学研究。将所得结果与通过高效液相色谱法（HPLC）获得的结果进行比较，以评估这种新RRA技术的有效性。
