Long T D, Kathol R G
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
Ann Clin Psychiatry. 1993 Dec;5(4):259-70. doi: 10.3109/10401239309148826.
Since the first reports of depressions associated with the use of reserpine, reports of affective syndromes related to the use of medications have proliferated in the literature. We chose to review controlled and uncontrolled studies, comprehensive reviews with comparisons of controlled studies, and case reports where sheer numbers indicated a relationship existed between affective syndromes and nonpsychotropic medications. Our findings suggest a relationship between the use of reserpine or lipophilic beta-blockers and depressive symptoms, but no clear evidence to support such a relationship with alpha-methyldopa, clonidine, calcium-channel blockers, or ACE-inhibitors. Glucocorticoids are related to both depressive symptoms and mania. Patients on anabolic steroids should be monitored for evidence of mania, rage, depression, and suicidality. There is no clear evidence that oral contraceptives are related to depressive symptoms. Our review does not support a close relationship between the use of H2 blockers, anticonvulsants, levodopa or antiarrhythmics, or antibiotics to affective syndromes.
自从首次报道与使用利血平相关的抑郁症以来，文献中关于使用药物引发情感综合征的报道激增。我们选择回顾对照研究和非对照研究、对照研究比较的综合综述以及病例报告，其中大量数据表明情感综合征与非精神药物之间存在关联。我们的研究结果表明，使用利血平或亲脂性β受体阻滞剂与抑郁症状之间存在关联，但没有明确证据支持与甲基多巴、可乐定、钙通道阻滞剂或血管紧张素转换酶抑制剂存在这种关联。糖皮质激素与抑郁症状和躁狂均有关联。使用合成代谢类固醇的患者应监测是否有躁狂、愤怒、抑郁和自杀倾向的迹象。没有明确证据表明口服避孕药与抑郁症状有关。我们的综述不支持使用H2阻滞剂、抗惊厥药、左旋多巴或抗心律失常药或抗生素与情感综合征之间存在密切关联。
