Bruun A, Ehinger B
Department of Ophthalmology, University of Lund, Sweden.
Acta Ophthalmol (Copenh). 1993 Oct;71(5):590-6. doi: 10.1111/j.1755-3768.1993.tb04647.x.
Neuropeptide Y (NPY) or closely related peptides are present in the retina of certain vertebrates, but their actions are not known. We have therefore studied the NPY-induced release of [3H]-GABA, [3H]-glycine, [3H]-dopamine, [3H]-5-hydroxytryptamine, and [3H]-choline chloride-derived radioactivity in the rabbit and chicken retina. NPY affected the release of [3H]-glycine, [3H]-dopamine, [3H]-5-hydroxytryptamine, and [3H]-choline chloride-derived radioactivity in rabbit retina and of [3H]-GABA, [3H]-5-hydroxytryptamine and [3H]-choline chloride-derived radioactivity in chicken retina in an energy requiring, NA+K(+)-ATPase dependent and calcium dependent manner. Certain related peptides, APP (= avian pancreatic polypeptide), BPP (= bovine pancreatic polypeptide), and PYY (= peptide YY), had variable and less pronounced effects. The results suggest a neurophysiological role in both chicken and rabbit retina for NPY or some related peptide.
神经肽Y（NPY）或与之密切相关的肽存在于某些脊椎动物的视网膜中，但其作用尚不清楚。因此，我们研究了NPY诱导的兔和鸡视网膜中[3H]-γ-氨基丁酸（GABA）、[3H]-甘氨酸、[3H]-多巴胺、[3H]-5-羟色胺以及[3H]-氯化胆碱衍生放射性物质的释放。NPY以能量依赖、钠钾（+）-ATP酶依赖和钙依赖的方式影响兔视网膜中[3H]-甘氨酸、[3H]-多巴胺、[3H]-5-羟色胺以及[3H]-氯化胆碱衍生放射性物质的释放，以及鸡视网膜中[3H]-GABA、[3H]-5-羟色胺和[3H]-氯化胆碱衍生放射性物质的释放。某些相关肽，如禽胰多肽（APP）、牛胰多肽（BPP）和肽YY（PYY），具有可变且不太明显的作用。结果表明，NPY或某些相关肽在鸡和兔视网膜中均具有神经生理作用。
