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鸡视网膜中某些神经肽释放神经递质。

Neurotransmitter release by certain neuropeptides in the chicken retina.

作者信息

Bauer B, Ehinger B, Tornqvist K, Waga J

出版信息

Acta Ophthalmol (Copenh). 1985 Oct;63(5):581-7. doi: 10.1111/j.1755-3768.1985.tb05248.x.

DOI:10.1111/j.1755-3768.1985.tb05248.x
PMID:2866656
Abstract

The ability of certain neuropeptides (glucagon, somatostatin, leu-enkephalin and neurotensin) to release known neurotransmitters (glycine, GABA, dopamine and 5-hydroxytryptamine) was tested in the chicken retina. Tritiated neurotransmitters were injected intravitreally in chicken eyes. After excision, the retina was stimulated in vitro with the neuropeptide in micromolar concentrations while monitoring the efflux of radioactivity from the retina. A rise of the efflux represents a stimulus dependent release. Neurotensin release [3H] glycine, [3H]dopamine and [3H]5-hydroxytryptamine. Leu-enkephalin released [3H]dopamine and somatostatin released [3H]5-hydroxytryptamine. Glucagon was without effect. [3H]GABA was not released by any of the neuropeptides.

摘要

在鸡视网膜中测试了某些神经肽(胰高血糖素、生长抑素、亮脑啡肽和神经降压素)释放已知神经递质(甘氨酸、γ-氨基丁酸、多巴胺和5-羟色胺)的能力。将氚标记的神经递质玻璃体内注射到鸡眼中。切除后,用微摩尔浓度的神经肽在体外刺激视网膜,同时监测视网膜放射性的流出。流出量的增加代表刺激依赖性释放。神经降压素释放[3H]甘氨酸、[3H]多巴胺和[3H]5-羟色胺。亮脑啡肽释放[3H]多巴胺,生长抑素释放[3H]5-羟色胺。胰高血糖素无作用。任何神经肽均未释放[3H]γ-氨基丁酸。

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The role of neurotensin in central nervous system pathophysiology: what is the evidence?神经降压素在中枢神经系统病理生理学中的作用:证据有哪些?
J Psychiatry Neurosci. 2006 Jul;31(4):229-45.
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