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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

O'Reilly R L, Davis B A

Department of Psychiatry, University of Western Ontario, London, Canada.

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jan;18(1):63-75. doi: 10.1016/0278-5846(94)90024-8.

The evidence that phenylethylamine (PEA) plays a role in the etiology of schizophrenia is reviewed. 2. PEA shares structural and physiological similarities with the amphetamines, the administration of which can induce a schizophrenia-like psychosis. 3. While there are a number of reports of high urinary PEA excretion in schizophrenic patients, the measurement of PEA in other body fluids and the measurement of phenylacetic acid (the major metabolite of PEA) has resulted in inconsistent findings. 4. The use of neuroleptic medication is a major confounding variable in most of the clinical studies. If PEA does have a role in the etiology of schizophrenia, the mechanism may involve PEAs ability to amplify dopamine responses.

本文综述了苯乙胺（PEA）在精神分裂症病因学中发挥作用的证据。2. PEA与安非他明在结构和生理上有相似之处，服用安非他明可诱发类似精神分裂症的精神病。3. 虽然有多项报告称精神分裂症患者尿中PEA排泄量高，但在其他体液中检测PEA以及检测苯乙酸（PEA的主要代谢产物）的结果并不一致。4. 在大多数临床研究中，使用抗精神病药物是一个主要的混杂变量。如果PEA确实在精神分裂症病因学中起作用，其机制可能涉及PEA放大多巴胺反应的能力。

O'Reilly R L, Davis B A

Department of Psychiatry, University of Western Ontario, London, Canada.

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jan;18(1):63-75. doi: 10.1016/0278-5846(94)90024-8.

The evidence that phenylethylamine (PEA) plays a role in the etiology of schizophrenia is reviewed. 2. PEA shares structural and physiological similarities with the amphetamines, the administration of which can induce a schizophrenia-like psychosis. 3. While there are a number of reports of high urinary PEA excretion in schizophrenic patients, the measurement of PEA in other body fluids and the measurement of phenylacetic acid (the major metabolite of PEA) has resulted in inconsistent findings. 4. The use of neuroleptic medication is a major confounding variable in most of the clinical studies. If PEA does have a role in the etiology of schizophrenia, the mechanism may involve PEAs ability to amplify dopamine responses.

本文综述了苯乙胺（PEA）在精神分裂症病因学中发挥作用的证据。2. PEA与安非他明在结构和生理上有相似之处，服用安非他明可诱发类似精神分裂症的精神病。3. 虽然有多项报告称精神分裂症患者尿中PEA排泄量高，但在其他体液中检测PEA以及检测苯乙酸（PEA的主要代谢产物）的结果并不一致。4. 在大多数临床研究中，使用抗精神病药物是一个主要的混杂变量。如果PEA确实在精神分裂症病因学中起作用，其机制可能涉及PEA放大多巴胺反应的能力。