精神分裂症患者的尿微量胺排泄及血小板单胺氧化酶活性

Urinary trace amine excretion and platelet monoamine oxidase activity in schizophrenia.

作者信息

Yoshimoto S, Kaku H, Shimogawa S, Watanabe A, Nakagawara M, Takahashi R

出版信息

Psychiatry Res. 1987 Jul;21(3):229-36. doi: 10.1016/0165-1781(87)90027-8.

Abstract

The relationship between subtypes of schizophrenia classified by ICD-9 and 24-hour urinary beta-phenylethylamine (PEA) and phenylacetic acid (PAA) excretion has been studied. Schizophrenia was divided into two types: paranoid and nonparanoid. Increased urinary PEA excretion was found in paranoid schizophrenics, but urinary PAA excretion did not show any significant difference between schizophrenics and normal subjects. A relationship between platelet monoamine oxidase (MAO) activity and urinary PEA excretion was found. These findings offer some indication that PEA may play a role in the pathogenesis of schizophrenia.

摘要

对按照国际疾病分类法第九版（ICD - 9）划分的精神分裂症亚型与24小时尿中β - 苯乙胺（PEA）及苯乙酸（PAA）排泄量之间的关系进行了研究。精神分裂症被分为两型：偏执型和非偏执型。发现偏执型精神分裂症患者尿中PEA排泄量增加，但精神分裂症患者与正常受试者之间尿中PAA排泄量未显示出任何显著差异。还发现血小板单胺氧化酶（MAO）活性与尿中PEA排泄量之间存在关联。这些发现表明PEA可能在精神分裂症的发病机制中起作用。