绵羊免疫球蛋白Cε基因座的组织：该基因5'端存在缺失的证据。

Organisation of the ovine immunoglobulin C epsilon gene locus: evidence for a deletion 5' of the gene.

作者信息

Clarke R A, Beh K J

机构信息

CSIRO Division of Animal Health, McMaster Laboratory, Glebe, N.S.W., Australia.

出版信息

Vet Immunol Immunopathol. 1993 Dec;39(4):381-93. doi: 10.1016/0165-2427(93)90069-g.

DOI:10.1016/0165-2427(93)90069-g

Abstract

A cosmid clone containing the ovine and C epsilon and C alpha immunoglobulin heavy chain genes was isolated and characterised. Restriction mapping and sequence analysis showed a high degree of similarity between the bovine and ovine C epsilon loci. Restriction fragment length polymorphism (RFLP) analysis of sheep genomic DNA revealed Mendelian inheritance of polymorphisms with identical variation in allele size for various restriction enzymes. This identical variation suggested that a deletion of approximately 100 bp existed at the 5' end of the smaller alleles.

摘要

分离并鉴定了一个包含绵羊Cε和Cα免疫球蛋白重链基因的黏粒克隆。限制性酶切图谱和序列分析表明，牛和绵羊的Cε基因座之间具有高度相似性。对绵羊基因组DNA的限制性片段长度多态性（RFLP）分析显示，多态性符合孟德尔遗传规律，不同限制性内切酶的等位基因大小存在相同的变异。这种相同的变异表明，较小等位基因的5'端存在约100 bp的缺失。

相似文献

1

Organisation of the ovine immunoglobulin C epsilon gene locus: evidence for a deletion 5' of the gene.绵羊免疫球蛋白Cε基因座的组织：该基因5'端存在缺失的证据。

Vet Immunol Immunopathol. 1993 Dec;39(4):381-93. doi: 10.1016/0165-2427(93)90069-g.

2

Characterization of the bovine epsilon gene.牛ε基因的特征描述。

Immunology. 1997 Nov;92(3):369-73. doi: 10.1046/j.1365-2567.1997.00352.x.

3

Molecular analysis and nematode resistance association of a polymorphism at the 5' end of the sheep IgE gene.

Vet Immunol Immunopathol. 2001 May 10;79(1-2):15-29. doi: 10.1016/s0165-2427(01)00246-x.

4

Isolation and sequence of sheep immunoglobulin E heavy-chain complementary DNA.绵羊免疫球蛋白E重链互补DNA的分离与测序

Vet Immunol Immunopathol. 1992 Oct;34(1-2):115-26. doi: 10.1016/0165-2427(92)90155-j.

5

Conserved organization of the murine immunoglobulin epsilon gene region: restriction endonuclease maps and switch-region nucleotide sequence.

J Immunol. 1987 Jul 15;139(2):603-7.

6

Partial sequence of the equine immunoglobulin epsilon heavy chain cDNA.马免疫球蛋白ε重链cDNA的部分序列

Vet Immunol Immunopathol. 1995 Aug;47(3-4):363-7. doi: 10.1016/0165-2427(94)05404-g.

7

Cloning of mouse immunoglobulin epsilon gene and its location within the heavy chain gene cluster.小鼠免疫球蛋白ε基因的克隆及其在重链基因簇中的定位。

Proc Natl Acad Sci U S A. 1981 Mar;78(3):1581-5. doi: 10.1073/pnas.78.3.1581.

8

Multiple recombinational events in primate immunoglobulin epsilon and alpha genes suggest closer relationship of humans to chimpanzees than to gorillas.灵长类免疫球蛋白ε和α基因中的多个重组事件表明，人类与黑猩猩的关系比与大猩猩的关系更密切。

J Mol Evol. 1988;27(1):77-83. doi: 10.1007/BF02099732.

9

Human immunoglobulin heavy chain A2 gene allotype determination by restriction fragment length polymorphism.通过限制性片段长度多态性检测人免疫球蛋白重链A2基因同种异型

Nucleic Acids Res. 1984 Feb 10;12(3):1303-11. doi: 10.1093/nar/12.3.1303.

10

Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing gamma, epsilon and alpha genes.人类免疫球蛋白重链恒定区基因的排列意味着包含γ、ε和α基因的片段发生了进化性重复。

Nature. 1982 Dec 23;300(5894):709-13. doi: 10.1038/300709a0.

引用本文的文献

1

Characterization of the bovine epsilon gene.牛ε基因的特征描述。

Immunology. 1997 Nov;92(3):369-73. doi: 10.1046/j.1365-2567.1997.00352.x.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。