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长效抗精神病药物治疗后出现两例长期多巴胺D2受体阻断的情况。

Two cases of long term dopamine D2 receptor blockade after depot neuroleptics.

作者信息

Harasko-van der Meer C, Brücke T, Wenger S, Fischer P, Deecke L, Podreka I

机构信息

Neurological University Clinic, Vienna, Austria.

出版信息

J Neural Transm Gen Sect. 1993;94(3):217-21. doi: 10.1007/BF01277026.

DOI:10.1007/BF01277026
PMID:7907218
Abstract

Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT. Dopamine D2 receptor occupancy 1.5 months after withdrawal still amounted to 83% and 50%. More attention should be focused on long term effects of neuroleptics.

摘要

对两名使用癸酸氟奋乃静后出现锥体外系副作用的患者进行了碘苄胍单光子发射计算机断层扫描（IBZM-SPECT）评估。停药1.5个月后多巴胺D2受体占有率仍分别高达83%和50%。应更加关注抗精神病药物的长期影响。

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1
Two cases of long term dopamine D2 receptor blockade after depot neuroleptics.长效抗精神病药物治疗后出现两例长期多巴胺D2受体阻断的情况。
J Neural Transm Gen Sect. 1993;94(3):217-21. doi: 10.1007/BF01277026.
2
The risk/benefit ratio of depot neuroleptics: a Scandinavian perspective.长效抗精神病药物的风险/效益比：斯堪的纳维亚视角
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Iodine-123-iodobenzamide SPECT assessment of dopamine D2 receptor occupancy in riperidone-treated schizophrenic patients.碘-123-碘苯甲酰胺单光子发射计算机断层扫描评估利培酮治疗的精神分裂症患者多巴胺D2受体占有率
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Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects.经典抗精神病药物和氯氮平治疗患者中枢D1和D2多巴胺受体占有率的正电子发射断层扫描分析。与锥体外系副作用的关系。
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Depot fluphenazine decanoate and enanthate for schizophrenia.用于治疗精神分裂症的癸酸氟奋乃静和庚酸氟奋乃静长效注射剂
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本文引用的文献

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In vivo assay for neuroleptic receptor binding in the striatum. Positron tomography in humans.
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Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs.接受抗精神病药物治疗的精神分裂症患者中枢D2-多巴胺受体占有率
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Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: correlative evaluation by positron emission tomography and plasma prolactin levels.抗精神病药物治疗期间及撤药后纹状体多巴胺受体占有率：正电子发射断层扫描与血浆催乳素水平的相关性评估
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Time course of D2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol.单次口服氟哌啶醇后通过正电子发射断层扫描（PET）检测D2-多巴胺受体占有率的时间进程。
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GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography.利用11C-雷氯必利和正电子发射断层扫描在体内测量GABA能对内源性多巴胺释放的抑制作用。
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8
Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects.经典抗精神病药物和氯氮平治疗患者中枢D1和D2多巴胺受体占有率的正电子发射断层扫描分析。与锥体外系副作用的关系。
Arch Gen Psychiatry. 1992 Jul;49(7):538-44. doi: 10.1001/archpsyc.1992.01820070032005.