Merri M, Alberti M, Moss A J
Department of Electrical Engineering, University of Rochester, NY 14627.
IEEE Trans Biomed Eng. 1993 Dec;40(12):1219-25. doi: 10.1109/10.250577.
Evaluation of the influence of the autonomic nervous system on the ventricular repolarization duration was carried out using beat-to-beat analysis of the time intervals between the peaks of the R and T waves (RTm). After pre-processing of digitized Holter ECG's, auto and cross spectrum analyses were applied to heart rate and repolarization duration variability signals. Coherence analysis was used to assess the existence of common spectral contributions. The heart rate variability signal was used as reference of the sympatho-vagal balance at the sinus node. It was found that, in normal individuals, the autonomic nervous system directly influences the ventricular repolarization duration and that this influence is qualitatively very similar to the one that modulates the heart rate. Pathological alteration of these parallel autonomic activities to the heart (on the sinus node and on the ventricle) might cause uncoupling between depolarization and repolarization.
利用逐搏分析R波与T波峰值之间的时间间隔（RTm），对自主神经系统对心室复极持续时间的影响进行了评估。在对数字化动态心电图进行预处理后，将自谱和互谱分析应用于心率和复极持续时间变异性信号。相干分析用于评估共同频谱成分的存在。心率变异性信号被用作窦房结交感-迷走平衡的参考。研究发现，在正常个体中，自主神经系统直接影响心室复极持续时间，且这种影响在性质上与调节心率的影响非常相似。这些与心脏（窦房结和心室）平行的自主活动的病理改变可能导致去极化和复极化之间的解耦。
