Porta Alberto, Bari Vlasta, Badilini Fabio, Tobaldini Eleonora, Gnecchi-Ruscone Tomaso, Montano Nicola
Department of Technologies for Health, Galeazzi Orthopedic Institute, University of Milan, Milan, Italy.
J Electrocardiol. 2011 Nov-Dec;44(6):662-8. doi: 10.1016/j.jelectrocard.2011.08.002. Epub 2011 Sep 9.
We test the hypothesis that the degree of correlation between ventricular repolarization duration (VRD) and heart period (HP) carries information on cardiac autonomic regulation. The degree of correlation was assessed in the frequency domain using squared coherence function during an experimental protocol known to gradually induce a shift of sympathovagal balance toward sympathetic predominance (ie, graded head-up tilt). We observed a progressive decrease of squared coherence with tilt table inclination, thus confirming the working hypothesis. The VRD-HP uncoupling occurs in the high-frequency band, centered on the respiratory rate, thus suggesting that vagal withdrawal is responsible for the VRD-HP uncoupling.
我们检验了这样一个假设,即心室复极持续时间(VRD)与心动周期(HP)之间的相关程度携带着心脏自主神经调节的信息。在一个已知会逐渐导致交感迷走神经平衡向交感神经占优势转变的实验方案(即分级头高位倾斜)过程中,使用平方相干函数在频域中评估相关程度。我们观察到平方相干性随倾斜台倾斜度逐渐降低,从而证实了该工作假设。VRD - HP解耦发生在以呼吸频率为中心的高频带,这表明迷走神经活动减弱是VRD - HP解耦的原因。