Malcolm R, Brady K T, Johnston A L, Cunningham M
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425.
J Psychoactive Drugs. 1993 Oct-Dec;25(4):315-9. doi: 10.1080/02791072.1993.10472289.
Records of inpatients (N = 1,483) over a three-year period at an addiction treatment center were evaluated for the presence of benzodiazepine (BZ) dependence (N = 136). The preferred BZ for 43% of the subjects was diazepam, and alprazolam for 14% of subjects. Chlordiazepoxide, lorazepam, and clorazepate were each the preferred BZ for 4% of patients. Cocaine and opioid abusers were six times more likely to abuse diazepam than any other BZ. Alprazolam patients required a significantly longer period of detoxification than diazepam patients. Four percent of BZ-dependent patients (N = 6) abused BZs only and had no other substance abuse history.
对一家戒毒治疗中心三年内的1483名住院患者记录进行评估,以确定苯二氮䓬(BZ)依赖情况(共136例)。43%的受试者首选地西泮作为BZ,14%的受试者首选阿普唑仑。氯氮卓、劳拉西泮和氯氮䓬钾分别为4%患者的首选BZ。可卡因和阿片类药物滥用者滥用地西泮的可能性是其他任何BZ的6倍。阿普唑仑患者的戒毒期明显长于地西泮患者。4%的BZ依赖患者(共6例)仅滥用BZ,无其他药物滥用史。