Jahnukainen K, Saari T, Morris I D, Salmi T T, Pöllänen P
Department of Anatomy, University of Turku, Finland.
Leukemia. 1994 Mar;8(3):458-64.
The testis is a common site of relapse in childhood acute lymphoblastic leukaemia (ALL). In adults, testicular relapses of ALL are very rare. A similar age-difference in the frequency of the testicular infiltration exists also in the rat T-cell leukaemia. In the present investigation, the effect of various hormonal treatments and unilateral cryptorchidism on the form of testicular infiltrates by the rat T-cell leukaemia was studied. Inhibition of testicular activity by estradiol treatment (E2) of early pubertal rats injected i.p. with rat T-leukaemic lymphoblasts significantly decreased the proportion of the testis occupied by leukaemic infiltrates. The proportion of the testis occupied by leukaemic infiltrates was significantly higher in the abdominal testes of both early and late pubertal unilaterally cryptorchid rats, than in the scrotal testes of leukaemic control rats. Daily treatment of early pubertal rats with human chorionic gonadotrophin (hCG), or human menopausal gonadotrophin (hMG), did not have an effect on testicular leukaemic infiltration. These studies demonstrate that the leukaemic infiltration of the testis is influenced by the changes in the physiological activity of the testes.
睾丸是儿童急性淋巴细胞白血病（ALL）常见的复发部位。在成人中，ALL的睾丸复发非常罕见。大鼠T细胞白血病的睾丸浸润频率也存在类似的年龄差异。在本研究中，研究了各种激素治疗和单侧隐睾对大鼠T细胞白血病睾丸浸润形式的影响。对青春期早期大鼠腹腔注射大鼠T白血病淋巴母细胞后用雌二醇（E2）治疗抑制睾丸活性，显著降低了白血病浸润所占据的睾丸比例。青春期早期和晚期单侧隐睾大鼠的腹腔睾丸中白血病浸润所占据的睾丸比例，显著高于白血病对照大鼠的阴囊睾丸。对青春期早期大鼠每日用人绒毛膜促性腺激素（hCG）或人绝经期促性腺激素（hMG）治疗，对睾丸白血病浸润没有影响。这些研究表明，睾丸的白血病浸润受睾丸生理活性变化的影响。
