Ramakrishna B S, Mathan M, Mathan V I
Wellcome Trust Research Laboratory, Dept. of Gastrointestinal Sciences, Christian Medical College Hospital, Vellore, India.
Scand J Gastroenterol. 1994 Jan;29(1):54-8. doi: 10.3109/00365529409090437.
Unabsorbed dietary unsaturated fatty acids may cause diarrhea in patients with steatorrhea, but their ability to cause colonic fluid secretion is not known. The present study investigated the effect of several dietary long-chain unsaturated fatty acids on colonic absorption and morphology in the rat colon in vivo. The fatty acids tested induced concentration-dependent net water secretion. The ability of these fatty acids to induce net water secretion varied as follows: linolenic acid (18:3) > linoleic acid (18:2), ricinoleic acid (18:1 OH) > oleic acid (18:1), palmitoleic acid (16:1). Net absorption of sodium and chloride were decreased in fatty acid perfusions. Mucosal activity of sodium potassium adenosine triphosphate and adenyl cyclase were not significantly altered by fatty acids. Epithelial cell damage was noted and correlated with the ability of the fatty acid to induce fluid secretion. Unsaturated fatty acids induce epithelial cell damage and fluid secretion in the colon, their effect being related to the degree of unsaturation.
未被吸收的膳食不饱和脂肪酸可能会导致脂肪泻患者出现腹泻，但它们引起结肠液分泌的能力尚不清楚。本研究调查了几种膳食长链不饱和脂肪酸对大鼠结肠体内结肠吸收和形态的影响。所测试的脂肪酸诱导了浓度依赖性的净水分分泌。这些脂肪酸诱导净水分分泌的能力变化如下：亚麻酸（18:3）>亚油酸（18:2），蓖麻油酸（18:1 OH）>油酸（18:1），棕榈油酸（16:1）。脂肪酸灌注时钠和氯的净吸收减少。脂肪酸对钠钾三磷酸腺苷和腺苷酸环化酶的黏膜活性没有显著改变。观察到上皮细胞损伤，且与脂肪酸诱导液体分泌的能力相关。不饱和脂肪酸会诱导结肠上皮细胞损伤和液体分泌，其作用与不饱和度程度有关。
