Grauer L, Barkin J S
University of Miami, School of Medicine/Division of Gastroenterology, Mt. Sinai Medical Center, FL 33140.
Digestion. 1994;55 Suppl 1:24-8. doi: 10.1159/000201185.
Somatostatin and its analogue (SMS 201-995, octreotide) have proven to effectively inhibit various gastrointestinal functions including exocrine and neuroendocrine secretion, motility and splanchnic blood flow. The long half-life and the ability to administer the analogue subcutaneously has liberalized its use in different intestinal and extraintestinal disorders. In particular, the profound inhibitory effects on exocrine pancreatic function have prompted the use of SMS in several pancreatic disorders. Despite the lack of controlled studies, somatostatin has been used in different pancreatic disorders, fistulas, pseudocysts and ascites. The preliminary evidence supports a definite role of this analogue as adjunctive and primary therapeutic agents.
生长抑素及其类似物（SMS 201-995，奥曲肽）已被证明能有效抑制各种胃肠功能，包括外分泌和神经内分泌分泌、蠕动及内脏血流。其较长的半衰期以及可皮下注射类似物的特性，使得它在不同的肠道和肠道外疾病中的应用更为广泛。特别是，它对外分泌胰腺功能的显著抑制作用促使其在多种胰腺疾病中得到应用。尽管缺乏对照研究，但生长抑素已被用于不同的胰腺疾病、瘘管、假性囊肿和腹水。初步证据支持这种类似物作为辅助和主要治疗药物的明确作用。
