Colombo P J, Thompson K R, Martinez J L, Bennett E L, Rosenzweig M R
Department of Psychology, University of California, Berkeley 94720.
Peptides. 1993 Nov-Dec;14(6):1165-70. doi: 10.1016/0196-9781(93)90171-c.
The opioid peptide dynorphin(1-13) impairs memory formation in chicks (5). We examined whether this occurs for both aversively and appetitively motivated learning. Four-day-old chicks were injected with dynorphin(1-13) into the intermediate medial hyperstriatum ventrale and trained on either a peck avoidance (PA) or an appetitive discrimination (AD) task; 2-day-old chicks were trained on PA. In 2-day-old chicks, dynorphin was amnestic for PA at 0.01, 0.03, or 0.1 mM. In 4-day-old chicks, dynorphin impaired memory formation for PA at 0.1 mM, and for AD training at 0.03 mM. Thus, similar doses of dynorphin impair memory formation for both appetitive and aversive conditioning.
阿片肽强啡肽（1-13）会损害雏鸡的记忆形成（5）。我们研究了这种情况是否发生在厌恶性和欲求性动机学习中。给4日龄雏鸡的腹内侧中间层纹状体注射强啡肽（1-13），并对其进行啄击回避（PA）或欲求性辨别（AD）任务训练；对2日龄雏鸡进行PA训练。在2日龄雏鸡中，0.01、0.03或0.1 mM的强啡肽对PA有遗忘作用。在4日龄雏鸡中，0.1 mM的强啡肽会损害PA的记忆形成，0.03 mM的强啡肽会损害AD训练的记忆形成。因此，相似剂量的强啡肽会损害欲求性和厌恶性条件反射的记忆形成。
