Martin P J, Evans D H, Naylor A R, Bell P R
Department of Neurology, Leicester Royal Infirmary, UK.
Ultrasound Med Biol. 1993;19(9):711-6. doi: 10.1016/0301-5629(93)90088-6.
Unlike conventional transcranial Doppler, transcranial colour coded sonography allows imaging of the basal cerebral arteries. We used this technique to determine blood flow velocities, with compensation for the angle of insonation, in the anterior and posterior cerebral circulation of 60 volunteers categorised by age (20-39, 40-59, > 60 years). Successful vessel insonation declined with increasing age: 40/40 middle cerebral arteries insonated 20-39 y, 31/40 insonated > 60 y. Peak, mean and end diastolic blood flow velocities also decreased with age in all arteries: 20-39 y middle cerebral artery mean velocity = 72 cm/s; > 60 y middle cerebral artery mean blood flow velocity = 58 cm/s; p < 0.0001. The pulsatility index increased significantly with age in the middle, posterior cerebral (P2 segment) and vertebral arteries (p < 0.05-0.005), however the resistance index increased significantly with age in all vessels (p < 0.05-0.0001).
与传统经颅多普勒不同，经颅彩色编码超声检查可对大脑基底动脉进行成像。我们运用该技术测定了60名按年龄分组（20 - 39岁、40 - 59岁、> 60岁）志愿者大脑前、后循环中的血流速度，并对声束角度进行了校正。随着年龄增长，成功探测到血管的比例下降：20 - 39岁组40条大脑中动脉中有40条被成功探测到，> 60岁组40条中有31条被成功探测到。所有动脉的血流峰值速度、平均速度和舒张末期血流速度均随年龄增长而下降：20 - 39岁组大脑中动脉平均速度 = 72 cm/s；> 60岁组大脑中动脉平均血流速度 = 58 cm/s；p < 0.0001。大脑中动脉、大脑后动脉（P2段）和椎动脉的搏动指数随年龄增长显著增加（p < 0.05 - 0.005），然而所有血管的阻力指数均随年龄增长显著增加（p < 0.05 - 0.0001）。
