Szydlik P, Mariak Z, Krejza J, Swiercz M, Keller A
Kliniki Neurochirurgii Akademii Medycznej w Białymstoku.
Neurol Neurochir Pol. 2000 May-Jun;34(3):523-36.
Transcranial colour-coded Doppler sonography enables estimation of blood flow parameters in the basal cerebral arteries. Reference values as well as age and gender dependence of these parameters are not sufficiently established in transcranial Doppler studies. There are no reports regarding blood flow in the respective arteries of the circle of Willis. Therefore we examined 185 healthy volunteers--82 men (mean age 47, range 20-78 years old) and 103 women (mean age 47, range 22-86 years old). The subjects were divided into three age groups: 20-40 years old (group I), 41-60 years old (group II) and more than 60 years old (group III). The examinations were performed via the temporal acoustic window with a 2.5 MHz probe. Angle-corrected peak systolic, mean and end-diastolic velocities as well as impedance indices were determined in the anterior, middle and posterior cerebral arteries. In the group I mean velocity values (mean +/- SD) for the anterior, middle and posterior arteries amounted to 56 +/- 14 cm/s, 81 +/- 20 cm/s and 52 +/- 12 cm/s, respectively. In group II the values were 53 +/- 16 cm/s, 73 +/- 19 cm/s and 51 +/- 12 cm/s, and in group III the values were 44 +/- 11 cm/s, 59 +/- 11 cm/s and 40 +/- 9 cm/s. Decline in the blood flow velocities and increase in the impedance indices were found in all vessels with advancing age. This was most pronounced in subjects who were more than 40 years old. The decrease with age in blood flow velocities was more substantial in the middle cerebral arteries than in the anterior and posterior cerebral arteries. In contrast, the impedance indices increased more distinctly in the anterior cerebral arteries than in the middle and posterior cerebral arteries. We have demonstrated that the blood flow Doppler parameters are age and, in the group I (20-40 years old), also gender dependent. The range of the normal reference values of these parameters has proved to be wide. Decrease with age in blood flow velocities was found to be varied in the major cerebral arteries.
经颅彩色编码多普勒超声检查能够评估大脑基底动脉的血流参数。在经颅多普勒研究中，这些参数的参考值以及年龄和性别依赖性尚未得到充分确立。目前尚无关于 Willis 环各动脉血流情况的报道。因此，我们对185名健康志愿者进行了检查，其中82名男性（平均年龄47岁，范围20 - 78岁）和103名女性（平均年龄47岁，范围22 - 86岁）。受试者被分为三个年龄组：20 - 40岁（第一组）、41 - 60岁（第二组）和60岁以上（第三组）。检查通过颞部声窗使用2.5MHz探头进行。在前、中、后大脑动脉中测定了角度校正后的收缩期峰值、平均和舒张末期速度以及阻抗指数。在第一组中，前、中、后动脉的平均速度值（平均值±标准差）分别为56±14cm/s、81±20cm/s和52±12cm/s。在第二组中，这些值分别为53±16cm/s、73±19cm/s和51±12cm/s，在第三组中分别为44±11cm/s、59±11cm/s和40±9cm/s。随着年龄增长，所有血管的血流速度均下降，阻抗指数升高。这在40岁以上的受试者中最为明显。大脑中动脉血流速度随年龄的下降比大脑前动脉和大脑后动脉更为显著。相比之下，大脑前动脉的阻抗指数升高比大脑中动脉和大脑后动脉更为明显。我们已经证明，血流多普勒参数与年龄有关，在第一组（20 - 40岁）中还与性别有关。这些参数的正常参考值范围很宽。发现大脑主要动脉中血流速度随年龄的下降情况各不相同。
