Dilova V, Shishkova V
Department of Galenical, Chemical Pharmaceutical Research Institute, Sofia, Bulgaria.
J Pharm Pharmacol. 1993 Nov;45(11):987-9. doi: 10.1111/j.2042-7158.1993.tb05642.x.
Four types of albumin microspheres containing dexamethasone prepared by varying cross-linking time--30, 60, 120 and 180 min--were tested to examine the influence of heat cross-linking degree on the in-vitro drug release. Release rate of dexamethasone associated with the microspheres was slower for samples with a longer time of high temperature denaturation. Encapsulation in heat-stabilized albumin microspheres for 60 min at 100 degrees C significantly retards the in-vivo release of dexamethasone and hence retards absorption from the injection site.
