Pavanetto F, Genta I, Giunchedi P, Conti B, Conte U
Dipartimento di Chimica Farmaceutica, Università di Pavia, Italy.
J Microencapsul. 1994 Jul-Aug;11(4):445-54. doi: 10.3109/02652049409034262.
This work deals with the preparation of corticosteroid-loaded albumin microspheres designed for intra-articular administration. Dexamethasone was chosen as the model drug and bovine serum albumin was used as the biodegradable, natural polymer. Albumin microspheres were produced by spray drying, a 'one-step' technique seldom used in the preparation of microparticulate drug delivery systems with particle sizes < 10 microns. The effects of both polymer/drug ratio used in the formulations and the different heat-stabilization conditions were evaluated on morphology, size, solubility characteristics, drug loading and 'in vitro' drug release of the microparticles.
本研究致力于制备用于关节腔内给药的载皮质类固醇白蛋白微球。选择地塞米松作为模型药物，牛血清白蛋白作为可生物降解的天然聚合物。白蛋白微球通过喷雾干燥制备，这是一种“一步法”技术，在制备粒径小于10微米的微粒药物递送系统中很少使用。评估了制剂中聚合物/药物比例和不同热稳定条件对微粒的形态、尺寸、溶解特性、药物负载和“体外”药物释放的影响。
