Kau R J, Wagner-Manslau C, Saumweber D M, Arnold W
Hals-Nasen-Ohren-Klinik, Technischen Universität München, Klinikum rechts der Isar.
Laryngorhinootologie. 1994 Jan;73(1):21-6. doi: 10.1055/s-2007-997074.
The development of a radiolabelled somatostatin analogue Indium-111-Pentetreotide makes the detection of somatostatin receptor-bearing tumours by scintigraphic techniques possible. The existence of high-affinity binding sites for somatostatin has been described previously for most endocrine active tumours of the gastroenteropancreatic system (GEP), malignant lymphomas, small cell lung carcinomas, a subgroup of breast tumours and several types of neuroendocrine related human tumours. Using this new diagnostic tool we investigated some head and neck tumours of neuroendocrine origin (carcinoid of larynx, Merkel cell carcinoma, paragangliomas) with the newly developed radiolabelled somatostatin analogue Indium-111-Pentetreotide whether in vivo visualisation of somatostatin receptors might be possible. In cases not accessible for surgery but with a positive receptor status we started a specific therapy with the somatostatin analogue octreotide. The preliminary results suggest that this new isotopic scanning technique in a diagnostic tool and a predictive method for an effective therapy of those head and neck tumours which revealed highly specifically a positive receptor status. The therapeutical results using the somatostatin analogue octreotide indicate that this new concept is an ideal therapeutic strategy for those neuroendocrine head and neck tumours which cannot be controlled by surgical procedures.
放射性标记的生长抑素类似物铟-111-奥曲肽的研发，使得通过闪烁扫描技术检测表达生长抑素受体的肿瘤成为可能。先前已有报道称，大多数胃肠胰系统（GEP）内分泌活性肿瘤、恶性淋巴瘤、小细胞肺癌、一部分乳腺肿瘤以及几种类型的神经内分泌相关人类肿瘤中存在生长抑素的高亲和力结合位点。我们使用这种新的诊断工具，利用新研发的放射性标记生长抑素类似物铟-111-奥曲肽，研究了一些神经内分泌起源的头颈部肿瘤（喉类癌、默克尔细胞癌、副神经节瘤），探究是否能够在体内可视化生长抑素受体。对于那些无法进行手术但受体状态呈阳性的病例，我们开始使用生长抑素类似物奥曲肽进行特异性治疗。初步结果表明，这种新的同位素扫描技术可作为一种诊断工具，也是对那些显示高度特异性阳性受体状态的头颈部肿瘤进行有效治疗的预测方法。使用生长抑素类似物奥曲肽的治疗结果表明，这一新概念对于那些无法通过手术控制的神经内分泌性头颈部肿瘤而言是一种理想的治疗策略。
