Hammond P J, Arka A, Peters A M, Bloom S R, Gilbey S G
Department of Medicine, Hammersmith Hospital, London, UK.
Q J Med. 1994 Feb;87(2):83-8.
Most gastroenteropancreatic tumours express somatostatin receptors, allowing imaging using radiolabelled somatostatin analogues. Octreotide can be modified by coupling a DTPA moiety to the N-terminal D-phenylalanine to allow labelling with In111. We studied the comparative effectiveness of this radiopharmaceutical in identifying tumour extent. Twenty-two patients with metastatic gastroenteropancreatic tumours were scanned using [111In-DTPA-D-Phe1]-octreotide. In 11 patients with the carcinoid syndrome, one of six primary lesions was identified by CT scanning and by [111In-DTPA-D-Phe1]-octreotide scanning. Hepatic metastases were present in all patients, 9 of whom had positive scintigraphy. Two other sites of intra-abdominal uptake and four distant sites, not previously identified, were demonstrated. Five other distant sites were confirmed to be carcinoid metastases. All 11 patients with other gastroenteropancreatic tumours had positive scans, demonstrating 7/9 primary lesions, 12 intra-abdominal lesions, including hepatic metastases in all cases, and one distant lesion, all previously identified. Thus [111In-DTPA-D-Phe1]-octreotide imaging effectively identified the extent of metastatic disease from gastroenteropancreatic tumours, and confirmed lesions whose significance was uncertain following previous imaging procedures.
大多数胃肠胰腺肿瘤表达生长抑素受体，这使得使用放射性标记的生长抑素类似物进行成像成为可能。奥曲肽可以通过将二乙三胺五乙酸（DTPA）部分偶联到N端的D-苯丙氨酸上进行修饰，以便用铟-111（In111）进行标记。我们研究了这种放射性药物在确定肿瘤范围方面的比较有效性。22例转移性胃肠胰腺肿瘤患者使用[111In-DTPA-D-Phe1] -奥曲肽进行扫描。在11例类癌综合征患者中，通过CT扫描和[111In-DTPA-D-Phe1] -奥曲肽扫描发现6个原发性病变中的1个。所有患者均有肝转移，其中9例闪烁扫描呈阳性。还发现了另外两个腹内摄取部位和4个先前未发现的远处部位。另外5个远处部位被证实为类癌转移。其他11例胃肠胰腺肿瘤患者扫描均呈阳性，显示出7/9个原发性病变、12个腹内病变（包括所有病例中的肝转移）和1个远处病变，这些病变均为先前已发现的。因此，[111In-DTPA-D-Phe1] -奥曲肽成像有效地确定了胃肠胰腺肿瘤转移性疾病的范围，并证实了先前成像检查后意义不明确的病变。
