Kakeji Y, Maehara Y, Adachi Y, Baba H, Mori M, Furusawa M, Sugimachi K
Department of Gastroenterologic Surgery, National Kyushu Cancer Center, Fukuoka, Japan.
Br J Cancer. 1994 Apr;69(4):749-53. doi: 10.1038/bjc.1994.141.
Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph nodes (P < 0.01), and these patients had a lower survival rate (P < 0.05). A significant correlation was recognised between the PCNA labelling percentage and AgNOR count (r = 0.452, P < 0.001). Cox's regression analysis showed that PCNA labelling percentage is an independent prognostic factor. These results indicate that estimating proliferative activity may be useful in predicting lymph node metastasis and patients' prognosis in cases of Borrmann type 4 gastric carcinoma.
采用增殖细胞核抗原（PCNA）标记百分比和嗜银核仁组成区（AgNOR）计数，对181例原发性Borrmann 4型胃癌的增殖活性进行了研究。增殖活性高的肿瘤常发生淋巴结转移（P<0.01），这些患者的生存率较低（P<0.05）。PCNA标记百分比与AgNOR计数之间存在显著相关性（r = 0.452，P<0.001）。Cox回归分析表明，PCNA标记百分比是一个独立的预后因素。这些结果表明，评估增殖活性可能有助于预测Borrmann 4型胃癌患者的淋巴结转移和预后。
