增殖细胞核抗原表达在胃癌中的预后价值及临床病理意义：一项系统评价与Meta分析
Prognostic value and clinicopathological significance of proliferating cell nuclear antigen expression in gastric cancer: a systematic review and meta-analysis.
作者信息
Yin Songcheng, Li Zhan, Huang Jinyu, Miao Zhifeng, Zhang Junyan, Lu Chunyang, Xu Hao, Xu Huimian
机构信息
Department of Surgical Oncology.
Department of Breast Surgery, First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.
出版信息
Onco Targets Ther. 2017 Jan 10;10:319-327. doi: 10.2147/OTT.S126551. eCollection 2017.
BACKGROUND
The prognostic significance of proliferating cell nuclear antigen (PCNA) expression in gastric cancer has long been assessed, yet results remain controversial. Therefore, we performed a meta-analysis to assess the prognostic value and clinicopathological significance of PCNA in gastric cancer.
METHODS
A systematic literature search of PubMed, EMBASE, and the Cochrane Library databases was conducted. Summary odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to investigate the correlations between PCNA expression and clinicopathological features, overall survival (OS), and disease-free survival (DFS).
RESULTS
A total of 19 studies involving 2,852 participants were included in our analysis. The pooled HR indicated that high PCNA expression was significantly associated with poor OS (HR 1.66, 95% CI 1.32-2.08) and DFS (HR 1.81, 95% CI 1.40-2.36). Subgroup analysis revealed that the association between PCNA and OS was also significant in Asian and European patients. In addition, the pooled ORs showed that high PCNA expression was significantly associated with deeper tumor invasion (OR 2.37, 95% CI 1.71-3.27), lymph node metastasis (OR 2.49, 95% CI 1.85-3.35), and advanced stage cancer (OR 1.89, 95% CI 1.36-2.63).
CONCLUSION
Our meta-analysis indicates that high PCNA expression might be a prognosticator of poor survival and a promising therapeutic target for gastric cancer patients.
背景
增殖细胞核抗原（PCNA）在胃癌中的预后意义长期以来一直受到评估，但结果仍存在争议。因此，我们进行了一项荟萃分析，以评估PCNA在胃癌中的预后价值和临床病理意义。
方法
对PubMed、EMBASE和Cochrane图书馆数据库进行系统的文献检索。计算汇总比值比（OR）和风险比（HR）以及95%置信区间（CI），以研究PCNA表达与临床病理特征、总生存期（OS）和无病生存期（DFS）之间的相关性。
结果
我们的分析共纳入了19项研究，涉及2852名参与者。汇总HR表明，PCNA高表达与较差的OS（HR 1.66，95%CI 1.32 - 2.08）和DFS（HR 1.81，95%CI 1.40 - 2.36）显著相关。亚组分析显示，PCNA与OS之间的关联在亚洲和欧洲患者中也具有显著性。此外，汇总OR显示，PCNA高表达与肿瘤浸润深度增加（OR 2.37，95%CI 1.71 - 3.27）、淋巴结转移（OR 2.49，95%CI 1.85 - 3.35）和晚期癌症（OR 1.89，95%CI 1.36 - 2.63）显著相关。
结论
我们的荟萃分析表明，PCNA高表达可能是胃癌患者生存不良的预后指标和一个有前景的治疗靶点。
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