Lin H Q, McGregor I S, Atrens D M, Christie M J, Jackson D M
Department of Pharmacology, University of Sydney, N.S.W., Australia.
Pharmacol Biochem Behav. 1994 Feb;47(2):369-74. doi: 10.1016/0091-3057(94)90025-6.
A series of experiments examined the role of dopamine in the conditioned taste aversion (CTA) produced by 3,4-methylenedioxymethamphetamine (MDMA) and d-amphetamine in rats. The CTA induced by MDMA (1.0 mg/kg) was unaffected by the D1 dopamine receptor antagonist SCH23390 (0.3 or 0.6 mg/kg), the D2 receptor antagonist raclopride (0.3 or 0.6 mg/kg), SCH23390 and raclopride combined (both 0.3 or 0.6 mg/kg), or the D1/D2 receptor antagonist haloperidol (0.4 mg/kg). In contrast, the CTA produced by d-amphetamine (0.5 mg/kg) was attenuated by SCH23390 and raclopride combined (both 0.3 mg/kg) as well as haloperidol (0.4 mg/kg), but not by SCH23390 (0.3 or 0.6 mg/kg) or raclopride (0.3 or 0.6 mg/kg) alone. These results suggest that dopamine plays different roles in MDMA and amphetamine CTAs, and that the D1 and D2 receptors independently mediate the aversive effect of amphetamine in CTA.
一系列实验研究了多巴胺在大鼠中由3,4-亚甲基二氧甲基苯丙胺（摇头丸）和右旋苯丙胺产生的条件性味觉厌恶（CTA）中的作用。摇头丸（1.0毫克/千克）诱导的CTA不受D1多巴胺受体拮抗剂SCH23390（0.3或0.6毫克/千克）、D2受体拮抗剂雷氯必利（0.3或0.6毫克/千克）、SCH23390和雷氯必利联合使用（均为0.3或0.6毫克/千克）或D1/D2受体拮抗剂氟哌啶醇（0.4毫克/千克）的影响。相比之下，右旋苯丙胺（0.5毫克/千克）产生的CTA被SCH23390和雷氯必利联合使用（均为0.3毫克/千克）以及氟哌啶醇（0.4毫克/千克）减弱，但单独使用SCH23390（0.3或0.6毫克/千克）或雷氯必利（0.3或0.6毫克/千克）则没有这种效果。这些结果表明，多巴胺在摇头丸和苯丙胺CTA中发挥不同作用，并且D1和D2受体独立介导苯丙胺在CTA中的厌恶作用。
