Zhang Y C, Huang L
Department of Physiology, Dalian Medical College.
Sheng Li Xue Bao. 1993 Oct;45(5):462-9.
The effect of Kappa-agonist dynorphin A-(1-13) on the urine flow was studied in ethanol-anesthetized rats. Intracerebroventricular injection of dynorphin A- (1-13) (5 micrograms, 10 micrograms) induced a potent diuretic response with insignificant action on mean arterial pressure and heart rate. The diuretic response began to show at about 20 min after injection and lasted 120 min. This diuretic effect could be almost completely blocked by pretreatment with naloxone (20 micrograms) or atropine (10 micrograms).
在乙醇麻醉的大鼠中研究了κ-激动剂强啡肽A-(1-13)对尿流的影响。脑室内注射强啡肽A-(1-13)(5微克、10微克)可引起强效利尿反应，而对平均动脉压和心率的作用不明显。利尿反应在注射后约20分钟开始出现，并持续120分钟。用纳洛酮(20微克)或阿托品(10微克)预处理可几乎完全阻断这种利尿作用。
