Jiang C L, Lin M Z
Department of Physiology, Dalian Medical University.
Sheng Li Xue Bao. 1994 Aug;46(4):361-8.
In anesthetized rats intracerebroventricular (i. c. v.) injection of cholinergic agonist carbachol induced significant natriuresis, kaliuresis and diuresis (P < 0.05). Among them, the degree of natriuresis was changed with carbachol in a dose-dependent manner (r = 0.9997, P < 0.05). These responses were completely blocked by cholinergic M receptor antagonist atropine or N receptor antagonist hexamethonium pretreatment. Such effects of carbachol were inhibited in part by pretreatment with adrenergic alpha receptor antagonist phentolamine. These results indicate that the natriuresis, kaliuresis and diuresis induced by i. c. v. injection of carbachol were primarily mediated by both muscarinic and nicotinic receptors in the brain, while the effect was in part mediated secondarily via adrenergic alpha receptor.
在麻醉大鼠中，脑室内注射胆碱能激动剂卡巴胆碱可诱导显著的利钠、利尿和尿钾增多（P<0.05）。其中，利钠程度随卡巴胆碱呈剂量依赖性变化（r = 0.9997，P<0.05）。这些反应可被胆碱能M受体拮抗剂阿托品或N受体拮抗剂六甲铵预处理完全阻断。卡巴胆碱的这种作用部分被肾上腺素α受体拮抗剂酚妥拉明预处理所抑制。这些结果表明，脑室内注射卡巴胆碱诱导的利钠、利尿和尿钾增多主要由脑中的毒蕈碱受体和烟碱受体介导，而该作用部分通过肾上腺素α受体间接介导。
