Kikuchi de Beltrán K, Koshikawa N, Miwa Y, Kobayashi M
Department of Pharmacology, Nihon University School of Dentistry, Tokyo, Japan.
Eur J Pharmacol. 1994 Jan 24;252(1):99-104. doi: 10.1016/0014-2999(94)90580-0.
The role of dorsal striatal mechanisms in the regulation of apomorphine-induced jaw movements was studied. Jaw movements induced by apomorphine (0.2 mg/kg i.v.) were potentiated by quinpirole (10 micrograms/0.2 microliter) injected into the dorsal part of the striatum 10 min before apomorphine. Quinpirole injection into the ventral part of the striatum did not affect the effects of apomorphine. the quinpirole-induced potentiation in the dorsal striatum was prevented by l-sulpiride (25 ng), nemonapride (1 microgram), SCH23390 (1 microgram) or methylscopolamine (1 microgram), but not muscimol (50 ng), co-administered with quinpirole. Injection of these drugs alone 10 min before apomorphine failed to alter the effects of apomorphine. l-Sulpiride (25 ng) injected into the dorsal striatum 60 min before apomorphine increased the frequency of jaw movements induced by apomorphine (0.2 mg/kg). The l-sulpiride-induced potentiation was prevented by methylscopolamine (0.1 microgram) or l-sulpiride (25 ng) injected into the dorsal striatum 10 min before apomorphine; we had already found that this potentiation was also blocked by SCH23390. It is suggested that a synergistic dopamine D1/D2 receptor interaction underlies both the quick-onset potentiation by quinpirole and the delayed-onset potentiation by l-sulpiride.
研究了背侧纹状体机制在阿扑吗啡诱导的下颌运动调节中的作用。在注射阿扑吗啡前10分钟，将喹吡罗（10微克/0.2微升）注入纹状体背侧，可增强阿扑吗啡（0.2毫克/千克静脉注射）诱导的下颌运动。将喹吡罗注入纹状体腹侧并不影响阿扑吗啡的作用。与喹吡罗共同给药时，L-舒必利（25纳克）、奈莫必利（1微克）、SCH23390（1微克）或甲基东莨菪碱（1微克）可阻止喹吡罗在背侧纹状体诱导的增强作用，但蝇蕈醇（50纳克）则不能。在注射阿扑吗啡前10分钟单独注射这些药物，未能改变阿扑吗啡的作用。在注射阿扑吗啡前60分钟将L-舒必利（25纳克）注入背侧纹状体，可增加阿扑吗啡（0.2毫克/千克）诱导的下颌运动频率。在注射阿扑吗啡前10分钟将甲基东莨菪碱（0.1微克）或L-舒必利（25纳克）注入背侧纹状体，可阻止L-舒必利诱导的增强作用；我们已经发现，这种增强作用也可被SCH23390阻断。提示喹吡罗的快速起效增强作用和L-舒必利的延迟起效增强作用均基于多巴胺D1/D2受体的协同相互作用。
