Gillette D W, Tannery L P
University of New Mexico School of Medicine, Albuquerque.
J Am Acad Child Adolesc Psychiatry. 1994 Feb;33(2):223-4. doi: 10.1097/00004583-199402000-00010.
Significant inhibition of tricyclic antidepressant metabolism by beta blockers has not often been cited in the literature and never in a clinical setting. We will describe two cases involving 9-year-old patients who experienced apparent inhibition of imipramine metabolism and near-toxic levels while receiving both propranolol and imipramine.
β受体阻滞剂对三环类抗抑郁药代谢的显著抑制在文献中并不常被提及，在临床环境中更是从未有过报道。我们将描述两例涉及9岁患者的病例，他们在同时接受普萘洛尔和丙咪嗪治疗时，出现了丙咪嗪代谢明显受抑制以及接近中毒水平的情况。
