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[儿童变形性肌张力障碍的个体化治疗]

[The differentiated treatment of dystonia musculorum deformans in children].

作者信息

Mal'mberg S A

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 1993;93(5):33-6.

PMID:7908772
Abstract

Thirty-eight children with deforming muscular dystonia were treated. Eighteen of them suffered from rigid, seven from hyperkinetic, and 13 from, mixed forms of the disease. To patients with rigid condition DOPA-containing drugs (nakom) were administered in combination with cholinolytics, diphenin, midocalm. If the condition proved resistant to therapy, parlodel, remantadin, antidepressants were added. To patients with hyperkinetic forms haloperidol, clonazepam, dephenin, finlepsin were administered. In mixed forms combinations of nakom with haloperidol and clonazepam were prescribed. The best results were attained in therapy of rigid forms (77% of all rigid forms), particularly of DOPA-dependent forms and those with local involvement.

摘要

对38例患有变形性肌营养不良症的儿童进行了治疗。其中18例为强直型,7例为多动型,13例为混合型。对于强直型患者,给予含多巴的药物(nakom)并联合胆碱能阻滞剂、苯妥英钠、米多卡姆。如果病情对治疗有抵抗性,则加用溴隐亭、金刚烷胺、抗抑郁药。对于多动型患者,给予氟哌啶醇、氯硝西泮、苯妥英钠、芬lepsin。在混合型中,开了nakom与氟哌啶醇和氯硝西泮的联合用药。强直型(占所有强直型的77%),尤其是多巴依赖型和局部受累型的治疗取得了最佳效果。

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