Dua H S, Gomes J A, Jindal V K, Appa S N, Schwarting R, Eagle R C, Donoso L A, Laibson P R
Research Division, Wills Eye Hospital, Philadelphia, PA.
Curr Eye Res. 1994 Jan;13(1):87-93. doi: 10.3109/02713689409042401.
Conjunctiva associated lymphoid tissue shows several similarities to mucosa associated lymphoid tissue of the gut and respiratory tract. These similarities have been described in relation to lymphocyte subpopulations and epithelial cell morphology. However, unlike the lymphoid tissue of the gut and respiratory tract, mucosa specific lymphocytes have not been described in the ocular mucosa. In this study we demonstrated the presence of mucosa specific lymphocytes bearing the Human Mucosal Lymphocyte-1 antigen (beta 7 integrin), in the human conjunctiva, limbus and lacrimal gland. The distribution of this subset of lymphocytes corresponded to the distribution of CD8+ T-cells and was found maximally in the epithelium of the epibulbar conjunctiva and in the lacrimal gland. The Human mucosal lymphocyte antigen may function to determine mucosal homing of this particular subset of CD8+ T-cells, which in turn, may have special function in immunological defense and tolerance mechanisms occurring at mucosal surfaces.
结膜相关淋巴组织与肠道和呼吸道的黏膜相关淋巴组织有若干相似之处。这些相似性已在淋巴细胞亚群和上皮细胞形态方面有所描述。然而，与肠道和呼吸道的淋巴组织不同，眼黏膜中尚未描述黏膜特异性淋巴细胞。在本研究中，我们证明了在人结膜、角膜缘和泪腺中存在携带人黏膜淋巴细胞-1抗原（β7整合素）的黏膜特异性淋巴细胞。该淋巴细胞亚群的分布与CD8 + T细胞的分布相对应，并且在眼球结膜上皮和泪腺中含量最高。人黏膜淋巴细胞抗原可能起到决定这一特定CD8 + T细胞亚群黏膜归巢的作用，而这反过来可能在黏膜表面发生的免疫防御和耐受机制中具有特殊功能。
